The phrase “With great power comes great responsibility” is commonly associated with Uncle Ben from Spider-Man, specifically said by the character Peter Parker’s uncle, Ben Parker, in the 2002 movie Spider-Man starring Tobey Maguire. However, the idea has been widely used and referenced in many forms of media and literature before that, often attributed to various sources like the Roman poet Voltaire, though it has become most famous through the Spider-Man franchise.