To URL-encode a query string in Python, you can use the urllib.parse module. This module provides a method to properly encode key-value pairs into a format suitable for URLs. The process involves creating a dictionary or list of key-value pairs and passing it to the encoding function.
For example, if you have data that needs to be included in a URL as query parameters, you encode it to ensure special characters are handled correctly. The resulting string can then be appended to a URL for safe transmission over the web.